Recently, effects of proresolving lipid mediators on periodontal disease pathogenesis have been investigated with understanding the roles in inflammation.One of these mediators, lipoxins, come into prominence by both antiinflammatory and proresolving effects. The aim of this study was to evaluate the periodontal parameters and serum lipoxin levels on individuals with achieved systemic risk factors for periodontal disease.180 volunteers (60 male, 111 female) who were categorised as systemically healthy, diabetic, hyperlipidaemic, obese and menopausal women, were recruited to this cross sectional study. Sociodemographics, disease status, medications and oral health behaviours were recorded via questionnaire. Clinical periodontal and metabolic parameters were evaluated. Serum lipoxin levels were analysed with ELISA.Clinic periodontal parameters were higher in systemically diseased groups then healthy ones. Serum lipoxin levels were higher in individuals with systemically healthy group with periodontitis and non-menopausal women with periodontitis within systemically diseased groups.Lipoxin levels were similar in systemically diseased groups but higher in systemically healthy group and non-menopausal women with periodontal disease and it could be important for suppressing inflammation and decreasing severe periodontal breakdown. Controlled longitudinal studies are needed in order to determine the role of lipoxins in systemic diseases. Keywords : Periodontal disease, Risk factors, Lipoxin.
Tez (Doktora) - Süleyman Demirel Üniversitesi, Sağlık Bilimleri Enstitüsü, Periodontoloji Anabilim Dalı, 2014.
Kaynakça var.
Recently, effects of proresolving lipid mediators on periodontal disease pathogenesis have been investigated with understanding the roles in inflammation.One of these mediators, lipoxins, come into prominence by both antiinflammatory and proresolving effects. The aim of this study was to evaluate the periodontal parameters and serum lipoxin levels on individuals with achieved systemic risk factors for periodontal disease.180 volunteers (60 male, 111 female) who were categorised as systemically healthy, diabetic, hyperlipidaemic, obese and menopausal women, were recruited to this cross sectional study. Sociodemographics, disease status, medications and oral health behaviours were recorded via questionnaire. Clinical periodontal and metabolic parameters were evaluated. Serum lipoxin levels were analysed with ELISA.Clinic periodontal parameters were higher in systemically diseased groups then healthy ones. Serum lipoxin levels were higher in individuals with systemically healthy group with periodontitis and non-menopausal women with periodontitis within systemically diseased groups.Lipoxin levels were similar in systemically diseased groups but higher in systemically healthy group and non-menopausal women with periodontal disease and it could be important for suppressing inflammation and decreasing severe periodontal breakdown. Controlled longitudinal studies are needed in order to determine the role of lipoxins in systemic diseases. Keywords : Periodontal disease, Risk factors, Lipoxin.