SAVRAN, Mehtap; ERZURUMLU, Yalçın; USTA SOFU, Gülşah; KARACA, Umut; CANDAN, İBRAHİM AYDIN; Hasseyid, Nursel; AŞCI, Halil
Description:
Purpose: Ramelteon (RML) is a potent, selective agonist of the high-affinity melatonin receptor 1 and 2 receptors. In addition, RML is known to have antioxidant and anti-inflammatory effects. In this study, we aimed to investigate the effects of RML on HIF-1 alpha, VEGF and e-NOS signaling pathway in a rat model of endotoxin-induced uveitis (EIU).