DSpace Repository

Capparis ovata Modulates Brain Oxidative Toxicity and Epileptic Seizures in Pentylentetrazol-Induced Epileptic Rats

Show simple item record

dc.creator NAZIROĞLU, Mustafa
dc.creator AKAY, Mehmet Berk
dc.creator YILDIRIM, Muhammed Ikbal
dc.creator BALCI, Erdinc
dc.creator YÜREKLİ, Vedat Ali
dc.creator ÇELİK, Ömer
dc.date 2013-03-31T21:00:00Z
dc.date.accessioned 2020-10-06T09:26:45Z
dc.date.available 2020-10-06T09:26:45Z
dc.identifier 138aba63-f995-4643-b1ed-ab21e99fc394
dc.identifier 10.1007/s11064-013-0978-3
dc.identifier https://avesis.sdu.edu.tr/publication/details/138aba63-f995-4643-b1ed-ab21e99fc394/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/53835
dc.description It has been widely suggested that oxidative stress products play an important role in the pathophysiology of epilepsy. Capparis ovata (C. ovata) may useful treatment of epilepsy because it contains antioxidant flavonoids. The current study was designed to determine the effects of C. ovata on lipid peroxidation, antioxidant levels and electroencephalography (EEG) records in pentylentetrazol (PTZ)-induced epileptic rats. Thirty-two rats were randomly divided into four groups. First group was used as control although second group was PTZ group. Oral 100 and 200 mg/kg C. ovata were given to rats constituting the third and fourth groups for 7 days before PTZ administration. Second, third and forth groups received 60 mg/kg PTZ for induction of epilepsy. Three hours after administration of PTZ, EEG records, brain cortex and blood samples were taken all groups. The lipid peroxidation levels of the brain cortex, number of spikes and epileptiform discharges of EEG were higher in PTZ group than in control and C. ovata group whereas they were decreased by C. ovata administration. Vitamin A, vitamin C, vitamin E and beta-carotene concentrations of brain cortex and latency to first spike of EEG were decreased by the PTZ administration although the brain cortex and plasma vitamin concentrations, and brain cortex and erythrocyte glutathione and glutathione peroxidase values were increased in PTZ + 100 and PTZ + 200 mg C. ovata groups. In conclusion, C. ovata administration caused protection against the PTZ-induced brain oxidative toxicity by inhibiting free radical and epileptic seizures, and supporting antioxidant redox system.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Capparis ovata Modulates Brain Oxidative Toxicity and Epileptic Seizures in Pentylentetrazol-Induced Epileptic Rats
dc.type info:eu-repo/semantics/article


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Browse

My Account