In this study, production rates of Xe-125,Xe-123 and Ba-133,Ba-131,Ba-129,Ba-128 medical isotopes produced by I-127(p, 3n)Xe-125, I-127(p, 5n)Xe-123, Cs-133(p, n)Ba-133mg, Cs-133(p, 3n)Ba-131mg, Cs-133(p, 5n)Ba-129, and Cs-133(p, 6n)Ba-128 reactions have been investigated up to 100 MeV incident proton energy. The pre-equilibrium calculations involve the hybrid model, the geometry-dependent hybrid model and the cascade exciton model. The calculated results are compared with the experimental data taken from the literature.