The nuclear data on (alpha, xn) reactions are very important in the fields of radiation shielding, long-term safe handling of spent fuel and spallation neutron-production. In this study, neutron-production cross sections have been calculated for some target nuclei such as Cu-65 and Bi-269. Hybrid model and geometry dependent hybrid model have been used to calculate the pre-equilibrium neutron-production cross sections. The mean free path parameter's effect for (alpha, xn) neutron-production cross section has been examined. The obtained results have been discussed and compared with the available experimental data. (C) 2010 Elsevier Ltd. All rights reserved.