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T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer
Drake, Charles G.; O'Neal, Tanya; Schaeffer, Edward M.; Allaf, Mohamad E.; Ertunc, Onur; Antonarakis, Emmanuel S.; Nirschl, Thomas R.; Obradovic, Aleksandar Z.; Liu, David; Chapman, Carolyn G.; Ross, Ashley E.; Partin, Alan W.; Cao, Haiyi; Zahurak, Marianna L.; Baena-Del Valle, Javier A.; Guner, Gunes; De Marzo, Angelo M.; Dallos, Matthew C.; Durham, Jennifer N.
Purpose: Previous studies suggest that androgen deprivation therapy (ADT) promotes antitumor immunity in prostate cancer. Whether a vaccine-based approach can augment this effect remains unknown.