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The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients

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dc.creator Bahcetepe, Dilek Cetiner
dc.creator Ataoglu, Ozlem
dc.creator Alici, Ozlem
dc.creator ULUKAVAK ÇİFTÇİ, TANSU
dc.creator KÖKTÜRK, NURDAN
dc.creator BABAYİĞİT, CENK
dc.creator KUL, SEVAL
dc.creator Cetinkaya, Pelin Duru
dc.creator NAYCI, SİBEL
dc.creator ARGUN BARIŞ, SERAP
dc.creator Karcioglu, Oguz
dc.creator AYSERT YILDIZ, PINAR
dc.creator IRMAK, İLİM
dc.creator Yuksel, Aycan Akbas
dc.creator Sekibag, Yonca
dc.creator BAYDAR TOPRAK, OYA
dc.creator AZAK KARALİ, EMEL
dc.creator Mulamahmutoglu, Sait
dc.creator Cuhadaroglu, Caglar
dc.creator Demirel, Aslihan
dc.creator KERGET, Buğra
dc.creator BARAN KETENCİOĞLU, BURCU
dc.creator ÖZGER, HASAN SELÇUK
dc.creator Ozkan, Gulcihan
dc.creator TÜRE YÜCE, ZEYNEP
dc.creator ERGAN, BEGÜM
dc.creator OĞUZ, VİLDAN AVKAN
dc.creator KILINÇ, OĞUZ
dc.creator Ercelik, Merve
dc.creator NURLU TEMEL, Esra
dc.creator Bayram, Hasan
dc.creator Itil, Oya
dc.creator KALYONCU, ALİ FUAT
dc.creator SAYINER, ABDULLAH
dc.creator ŞAKAR COŞKUN, AYŞIN
dc.creator Ozkan, Metin
dc.creator Havlucu, Yavuz
dc.creator Gultekin, Okkes
dc.creator Eyuboglu, Fusun Oner
dc.creator Gulhan, Erkmen
dc.creator Edis, Ebru Cakir
dc.creator Dursun, Berna
dc.creator Altinisik, Goksel
dc.creator AKGÜN, Metin
dc.creator UZUN, OĞUZ
dc.creator Sagcan, Gulseren
dc.creator Okur, Hacer Kuzu
dc.creator HANTA, İSMAİL
dc.creator Elbek, Osman
dc.creator Bayraktar, Firat
dc.creator GEMİCİOĞLU, Bilun
dc.creator BÖREKÇİ, Şermin
dc.creator OĞUZÜLGEN, İPEK KIVILCIM
dc.creator BOYACI, HAŞİM
dc.creator BAŞYİĞİT, İLKNUR
dc.creator Gulhan, Pinar Yildiz
dc.creator DİKENSOY, ÖNER
dc.creator ÖZTÜRK, Önder
dc.creator Tuna, Tibel
dc.creator Turgut, Teyfik
dc.creator Altin, Sedat
dc.creator Gunluoglu, Gulsah
dc.creator TOR, MÜGE MELTEM
dc.creator Kose, Neslihan
dc.creator DEVECİ, FİGEN
dc.creator Fakili, Fusun
dc.creator Gullu, Yusuf Taha
dc.creator Aydin, Asena
dc.date 2021-07-01T00:00:00Z
dc.date.accessioned 2021-12-03T11:32:24Z
dc.date.available 2021-12-03T11:32:24Z
dc.identifier 95095adb-2303-4328-9092-5e758a00baa5
dc.identifier 10.1016/j.rmed.2021.106433
dc.identifier https://avesis.sdu.edu.tr/publication/details/95095adb-2303-4328-9092-5e758a00baa5/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/93413
dc.description The COVID-19-related death rate varies between countries and is affected by various risk factors. This multi-center registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2%). Among all cases, 1144 (76.3%) were diagnosed with non-severe pneumonia, whereas 212 (14.1%) had severe pneumonia. Death occurred in 67 patients, corresponding to a mortality rate of 4.5% (95% CI:3.5-5.6). The univariate analysis demonstrated that various factors, including male sex, age >= 65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were positively associated with mortality. Favipiravir, hydroxychloroquine and azithromycin were not associated with survival. Following multivariate analysis, male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were found to be independent risk factors for mortality. Among the biomarkers, procalcitonin levels on the 3rd-5th days of admission showed the strongest associations with mortality (OR: 6.18; 1.6-23.93). This study demonstrated that the mortality rate in hospitalized patients in the early phase of the COVID-19 pandemic was a serious threat and that those patients with male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were at increased risk of mortality; therefore, such patients should be closely monitored.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients
dc.type info:eu-repo/semantics/article


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