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In Silico and In Vitro Antiproliferative Activity Assessment of New Schiff Bases

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dc.creator AKKOÇ, Senem
dc.creator Aslan, Guzin
dc.creator TÜZÜN, BURAK
dc.creator Karata, Halis
dc.date 2022-01-01T00:00:00Z
dc.date.accessioned 2022-05-10T11:31:29Z
dc.date.available 2022-05-10T11:31:29Z
dc.identifier f8b0c433-6c6b-4df0-9388-e711f37f8431
dc.identifier 10.1002/slct.202103679
dc.identifier https://avesis.sdu.edu.tr/publication/details/f8b0c433-6c6b-4df0-9388-e711f37f8431/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/97050
dc.description In this study, a series of new Schiff bases, based on a pyrimidine core, were synthesized in two steps. The structures of these newly synthesized Schiff bases were completely characterized. The presence of characteristic -N=CH proton peaks proving the formation of imine supports the structures of the compounds. The cytotoxic activity studies were done towards human cancer cell lines. The results show that the related molecules had antiproliferative activity on cancerous cells. To compare the chemical and biological activities of pyrimidine derivatives were performed using Gaussian software and Maestro Molecular modeling platform by Schrodinger, respectively. Afterwards, ADME/T analysis was performed to examine the possibility of pyrimidine derivatives being drugs.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title In Silico and In Vitro Antiproliferative Activity Assessment of New Schiff Bases
dc.type info:eu-repo/semantics/article

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