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Effects of permanent placental injury due to severe acute respiratory syndrome coronavirus 2 infection during pregnancy on the feto-placental circulation: a cross-sectional study

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dc.creator BOZKURT, Kemal Kürşat
dc.creator BAYHAN, Gökhan
dc.creator Turgut, Ümran Kılınçdemir
dc.creator KILÇAR, Mihriban
dc.date 2024-01-01T00:00:00Z
dc.date.accessioned 2025-02-25T10:33:16Z
dc.date.available 2025-02-25T10:33:16Z
dc.identifier 83b26540-9c7f-4862-82e5-59dc5b22fc3e
dc.identifier 10.1590/1806-9282.20230827
dc.identifier https://avesis.sdu.edu.tr/publication/details/83b26540-9c7f-4862-82e5-59dc5b22fc3e/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/100377
dc.description OBJECTIVE: The aim of this study was to evaluate the effects of permanent placental injury due to a severe acute respiratory syndrome coronavirus 2 infection during pregnancy on feto-placental circulation. METHODS: In this cross-sectional study, 83 pregnant women with planned deliveries were divided into two groups according to their severe acute respiratory syndrome coronavirus 2 infection statuses during pregnancy. Their demographic parameters, obstetric histories, and prenatal risks were evaluated. A prenatal fetal Doppler ultrasound examination was performed for all participants, and umbilical artery and middle cerebral artery Doppler parameters were obtained. Postpartum placentas were examined for pathological findings under appropriate conditions. All placentas were evaluated according to the Amsterdam consensus criteria. Mann-Whitney U test, Student’s t-test, and chi-square test were used for comparisons. RESULTS: Demographic parameters were statistically similar, except that they were borderline significant for gestational weeks at delivery (p=0.044). In the pathological examination of the placenta, regardless of the trimester of exposure to viral infection, perivillous fibrin deposition and villus dystrophic calcification were more common in group 2 (p=0.016 and p=0.048, respectively) than in group 1. In the prenatal Doppler examination between the groups, no statistically significant difference was found for all of the umbilical artery pulsatile index, middle cerebral artery pulsatile index, and cerebro-placental ratio values. CONCLUSION: Severe acute respiratory syndrome coronavirus 2 infection during pregnancy causes an increase in perivillous fibrin deposition and villus dystrophic calcification in the placenta. Placental injury caused by the severe acute respiratory syndrome coronavirus 2 virus does not affect fetal Doppler parameters.
dc.language eng
dc.rights info:eu-repo/semantics/openAccess
dc.title Effects of permanent placental injury due to severe acute respiratory syndrome coronavirus 2 infection during pregnancy on the feto-placental circulation: a cross-sectional study
dc.type info:eu-repo/semantics/article


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