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Background: The goal of this study was to analyze the prophylactic effects of quercetin (Qu) against testes damage induced by 2600 MHz electromagnetic field (EMF) in rats. Materials and Methods: Thirty-two male rats (Wistar-Albino) were indiscriminately separated into four groups which were named: Control, Sham-exposed, EMF-exposed (EMF, 1 h day−1 for 30 days), and EMF + Qu (100 mg/kg/daily) groups. After 30 days, the rats were sacrificed, testicular tissues were taken, and routine procedures were performed for histological and immunohistochemical evaluations. Results: When the testicular tissue of the control group was evaluated histopathologically, it was concluded that structures such as Leydig cells and seminiferous tubules were in normal condition and there was no change. No bleeding or inflammation was observed in the general structure of testicular tissues. Irregularities in spermatogenic cell configuration and shedding in the seminiferous epithelium were observed in the EMF and EMF + Qu groups. Findings close to our control group were detected in the sham-exposed and EMF + Qu groups. In addition, tumor necrosis factor-α (TNF-α) immune reactions in were EMF+ Qu group was decreased compared to the EMF group. Conclusion: In histopathological and immunohistochemical evaluation, it has been proven that EMF causes damage to testicular tissue. However, Qu demonstrated partial ameliorative effects on the pathological findings of the current study. |
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