| dc.creator |
ÇEMREK, FATİH |
|
| dc.creator |
Eker Sarıboyacı, Ayla |
|
| dc.creator |
Demir Güçlüer, Zilif |
|
| dc.creator |
SEVİMLİ, Murat |
|
| dc.creator |
İNAN, ULUKAN |
|
| dc.creator |
Nur Soykan, Merve |
|
| dc.creator |
Altuğ Tasa, Burcugül |
|
| dc.creator |
Qomi Ekenel, Emilia |
|
| dc.creator |
GÜNEŞ BAĞIŞ, SİBEL |
|
| dc.creator |
SEMERCİ SEVİMLİ, TUĞBA |
|
| dc.creator |
UYSAL, ONUR |
|
| dc.date |
2023-05-20T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:34:34Z |
|
| dc.date.available |
2025-02-25T10:34:34Z |
|
| dc.identifier |
9627159b-41ab-4b68-a602-b4fd00ba0813 |
|
| dc.identifier |
10.1016/j.gene.2023.147337 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/9627159b-41ab-4b68-a602-b4fd00ba0813/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/100633 |
|
| dc.description |
This study aimed to investigate the differences between the exosomal microRNA-127-5p expression profiles of human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) and human synovial fluid-derived mesenchymal stem cells (hSF-MSCs) during chondrogenesis in terms of regenerative treatment of cartilage. Synovial fluid-derived mesenchymal stem cells, adipose tissue-derived mesenchymal stem cells, and human fetal chondroblast cells (hfCCs) were directed to chondrogenic differentiation. Alcian Blue and Safranin O stainings were performed to detect chondrogenic differentiation histochemically. Exosomes derived from chondrogenic differentiated cells and their exosomes were isolated and characterized. microRNA-127-5p expressions were measured by Quantitative reverse transcription PCR (qRT-PCR). Significantly higher levels of microRNA-127-5p expression in differentiated hAT-MSCs exosomes, similar to human fetal chondroblast cells, which are the control group in the chondrogenic differentiation process, were observed. hAT-MSCs are better sources of microRNA-127-5p than hSF-MSCs for stimulating chondrogenesis or in the regenerative therapy of cartilage-related pathologies. hAT-MSCs exosomes are rich sources of microRNA-127-5p and can be an essential candidate for cartilage regeneration treatments. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Comparison of exosomes secreted by synovial fluid-derived mesenchymal stem cells and adipose tissue-derived mesenchymal stem cells in culture for microRNA-127-5p expression during chondrogenesis |
|
| dc.type |
info:eu-repo/semantics/article |
|