| dc.creator |
Dilek, Ömer |
|
| dc.creator |
Ertürk, Erkan |
|
| dc.creator |
Patir, Süleyman |
|
| dc.creator |
TİLKİ, Tahir |
|
| dc.date |
2023-07-11T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:34:52Z |
|
| dc.date.available |
2025-02-25T10:34:52Z |
|
| dc.identifier |
9acbf999-87c9-4f31-b9ba-aff405999689 |
|
| dc.identifier |
10.1016/j.tetlet.2023.154603 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/9acbf999-87c9-4f31-b9ba-aff405999689/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/100697 |
|
| dc.description |
It is introduced that an N-MOM-tetrahydrocarbazole-fused tetrahydrofuran is a new intermediate for the synthesis of olivacine. Upon treatment with DDQ in a mixture of H2O-THF at 80 °C, it undergoes ring-opening, MOM-removal and aromatization in one pot to yield 1-methyl-carbazole-2-ethanol, an already known precursor for olivacine. Besides, several common transformations, such as α-alklylation of N-MOM-protected tetrahydrocarbazole-1-one with ethyl bromoacetate and reduction of a lactone to tetrahydrofuran with Red-Al, have been made good use. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
A DDQ-mediated ring-opening and aromatization cascade of a tetrahydrocarbazole-fused tetrahydrofuran for the synthesis of olivacine |
|
| dc.type |
info:eu-repo/semantics/article |
|