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Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia

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dc.creator Akdogan, Nurdan
dc.creator Ozel, Selinay
dc.creator NURALIN, LEVENT
dc.creator DİŞLİ, ALİ
dc.creator DOYDUK, DOĞUKAN
dc.creator Ogutcu, Hatice
dc.creator Dilek, Gulay
dc.creator AKKOÇ, Senem
dc.date 2024-01-01T00:00:00Z
dc.date.accessioned 2025-02-25T10:39:40Z
dc.date.available 2025-02-25T10:39:40Z
dc.identifier dd10a0d6-8d44-4a25-bb4f-a5d34ae6eef5
dc.identifier 10.1080/14786419.2024.2443500
dc.identifier https://avesis.sdu.edu.tr/publication/details/dd10a0d6-8d44-4a25-bb4f-a5d34ae6eef5/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/101602
dc.description The constituents of the aqueous, ethanol, hexane, and methanol extracts of Anatolian propolis collected from the Eastern Black Sea Region (Çayeli-Rize) were investigated by GC–MS, HPLC and AAS. Interestingly, lactulose has been identified. Ten phenolic compounds, namely caffeic acid, ferulic acid, rutin, taxifolin, quercetin, kaempferol, apigenin, silicristin, silibinin and gallic acid were determined. The contents of phenolic acids and flavonoids varied between 17.04–642.59 and 1.18–2749.20 ppm, respectively. Minerals found in propolis were Na, K, Ca, Mg and Zn. The methanol extract had the highest antiproliferative activity against the A549 cell line with an IC50 value of 0.1821 µL/mL. The extracts showed higher antibacterial activity against Gram-negative bacteria compared to Gram-positive bacteria.
dc.language eng
dc.rights info:eu-repo/semantics/openAccess
dc.title Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia
dc.type info:eu-repo/semantics/article


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