| dc.creator |
GÖKÇE, Başak |
|
| dc.creator |
Çıkrıkçı, Kübra |
|
| dc.creator |
ŞAHUTOĞLU, ARİF SERCAN |
|
| dc.creator |
Gençer, Nahit |
|
| dc.creator |
BERBER, NURCAN |
|
| dc.date |
2023-11-05T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:40:37Z |
|
| dc.date.available |
2025-02-25T10:40:37Z |
|
| dc.identifier |
e6f470b4-ddad-4211-bee6-6a0d0025268c |
|
| dc.identifier |
10.1016/j.molstruc.2023.136061 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/e6f470b4-ddad-4211-bee6-6a0d0025268c/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/101760 |
|
| dc.description |
Phenylthiazol-2(3h)-ylidene-isoquinoline-5-amine derivatives(5a-r) were easily prepared from 5-aminoisoquinoline, thioisocyanate, and phenacyl bromide derivatives in the presence of triethylamine in tetrahydrofuran (THF), and dimethyl formamide (DMF) in two steps. In the first step, thiourea was synthesized in THF reflux, 24 h and then in the second step, the formation of thiazole ring was ensured in EtOH-DMF (5:5 v/v), reflux, 24 h. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, and elemental analysis. The inhibitory effects of 18 newly synthesized compounds (5a-r) on hydratase and esterase activities of carbonic anhydrase isoenzymes (hCA I, II, IX, and X) were studied in vitro. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis, characterization, carbonic anhydrase inhibitor activity, and docking studies of phenylthiazol-2(3h)-ylidene-isoquinoline-5-amine Derivatives |
|
| dc.type |
info:eu-repo/semantics/article |
|