| dc.creator |
AKKOÇ, Senem |
|
| dc.date |
2024-11-01T00:00:00Z |
|
| dc.date.accessioned |
2025-02-25T10:40:57Z |
|
| dc.date.available |
2025-02-25T10:40:57Z |
|
| dc.identifier |
eb454c3b-1a15-4676-a27e-da77faaa10cd |
|
| dc.identifier |
10.1016/j.jics.2024.101445 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/eb454c3b-1a15-4676-a27e-da77faaa10cd/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/101815 |
|
| dc.description |
In this study, a known benzimidazolium salt was synthesized in two steps starting from N-phenyl-o-phenylenediamine. This compound was tested in vitro for 72 h against different cancer cell lines (A549 - lung cancer, HepG2 - liver cancer, DLD-1 - colon cancer) and to compare the activity of this compound with cisplatin, a widely used chemotherapeutic agent. The evaluation of compound 4 as a potential anticancer agent against different cancer types was achieved by examining the cytotoxic effects of this compound through IC50 values using the MTT method. It was found that compound 4 showed different activity depending on the cell type and had a high cytotoxic effect (IC50: 15.68 μM), especially against lung cancer cell line for 72 h incubation time. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Cytotoxic activity properties of a benzimidazolium salt against lung, liver, and colon cancer cell lines |
|
| dc.type |
info:eu-repo/semantics/article |
|