| dc.creator |
Erten, Nilgün.
author
24187 |
|
| dc.creator |
Demirci, Serpil,
1965-
thesis advisor
18517 |
|
| dc.creator |
Süleyman Demirel Üniversitesi.
Tıp Fakültesi.
Nöroloji Anabilim Dalı.
issuing body
11613 |
|
| dc.date |
2009. |
|
| dc.identifier |
http://tez.sdu.edu.tr/Tezler/TT00482.pdf |
|
| dc.description |
Stroke is one of the major causes of long-term disability which brings about psychical and socioeconomic drawbacks for patients and their parents as well as medical institutions. In effect, it should form a basis in combating with the stroke to ascertain the risk factors and to eliminate these factors. Major diversities have been reported in the studies conducted for purposes of stroke etiology. The scarcity of the samples in the studies, the variety of the methods applied and the ethnic groups have highly likely contributed to the diversity of the results. The objective of this study has been to investigate the frequency of the prothrombin gene mutation on the progress of stroke. In our study, we have examined 238 patients who have not been struck by stroke and 238 stroke patients. Following the study, occurrence rates of merely Factor V H1299R, Factor V Leiden and . Fibrinojen -455GA mutations have been found expressively high in the stroke patients in comparison to control group (p<0.05). Statistical significance of these mutations has vanished as a result of logistic regression analysis (p>0.05). Some other prothrombotical mutations such as Factor XIII V34L, MTHFR A1298C and MTHFR C677T have been detected in high ratios in both groups. However, no statistically significant difference has been found between the patient group and control group. To sum up, in the light of these information we have drawn the conclusion that the stroke ethiopathogenesis is multifactorial and that prothrombotical gene mutations can only form a risk factor when they appear together with other factors.
Keywords: Stroke, Prothrombine gene mutations, Risk factors. |
|
| dc.description |
Tez (Tıpta Uzmanlık) - Süleyman Demirel Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, 2009. |
|
| dc.description |
Kaynakça var. |
|
| dc.description |
Stroke is one of the major causes of long-term disability which brings about psychical and socioeconomic drawbacks for patients and their parents as well as medical institutions. In effect, it should form a basis in combating with the stroke to ascertain the risk factors and to eliminate these factors. Major diversities have been reported in the studies conducted for purposes of stroke etiology. The scarcity of the samples in the studies, the variety of the methods applied and the ethnic groups have highly likely contributed to the diversity of the results. The objective of this study has been to investigate the frequency of the prothrombin gene mutation on the progress of stroke. In our study, we have examined 238 patients who have not been struck by stroke and 238 stroke patients. Following the study, occurrence rates of merely Factor V H1299R, Factor V Leiden and . Fibrinojen -455GA mutations have been found expressively high in the stroke patients in comparison to control group (p<0.05). Statistical significance of these mutations has vanished as a result of logistic regression analysis (p>0.05). Some other prothrombotical mutations such as Factor XIII V34L, MTHFR A1298C and MTHFR C677T have been detected in high ratios in both groups. However, no statistically significant difference has been found between the patient group and control group. To sum up, in the light of these information we have drawn the conclusion that the stroke ethiopathogenesis is multifactorial and that prothrombotical gene mutations can only form a risk factor when they appear together with other factors.
Keywords: Stroke, Prothrombine gene mutations, Risk factors. |
|
| dc.language |
tur |
|
| dc.publisher |
Isparta : SDÜ Tıp Fakültesi, |
|
| dc.subject |
Süleyman Demirel Üniversitesi |
|
| dc.title |
İnme olgularında protrombin gen mutasyonlarının rolü = The role of prothrombine gen mutations in stroke / |
|
| dc.type |
text |
|