| dc.creator |
YASAR SIRIN, Duygu |
|
| dc.creator |
AKALAN, Hande |
|
| dc.date |
2018-08-15T00:00:00Z |
|
| dc.date.accessioned |
2019-07-09T11:59:01Z |
|
| dc.date.available |
2019-07-09T11:59:01Z |
|
| dc.identifier |
http://dergipark.org.tr/sdufenbed/issue/38975/456311 |
|
| dc.identifier |
10.19113/sdufbed.99971 |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/46079 |
|
| dc.description |
Prognostic molecular markers identified in leukemia are becoming increasingly important especially in risk stratification and to determine therapy. In this study, we investigate the role of ELK-1 transcription factor and its potential target genes in four cell lines; Daudi, Jurkat, K-562 and HL-60. To evaluate ELK-1, MCPIP, MCL-1, BCL-10, CEBPB and SRF genes expression profiles we have performed a Real-time PCR analysis on Daudi, Jurkat, K-562 and HL-60 cell lines. ELK-1 over expression concomitant with SRF overexpression was detected only in Daudi cell line while only SRF overexpression was detected in jurkat cells. Expression of MCPIP, MCL-1, BCL-10 and CEBPB genes were decreased in all cell lines. Protein levels or phosphorylation status of ELK-1, BCL-10, CEBPB, MCL-1, MCPIP and SRF, moreover, changes that may occur when ELK-1 continuous overexpression is provided or completely silenced in these cell lines have not been evaluated. These questions are suggestions for future investigations. |
|
| dc.format |
application/pdf |
|
| dc.publisher |
Süleyman Demirel University |
|
| dc.publisher |
Süleyman Demirel Üniversitesi |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/528902 |
|
| dc.source |
Volume: 22, Issue: 2
388-392 |
en-US |
| dc.source |
1308-6529 |
|
| dc.subject |
ELK-1,ELK-1 Target Genes; Expression profile |
|
| dc.title |
Expression Profile of Transcription Factor ELK-1 and ELK-1 Target Genes on Lymphoma-Leukemia Cell Lines |
en-US |
| dc.type |
info:eu-repo/semantics/article |
|