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Electrochemical sensing and fluorescence imaging of E. coli O157:H7 based on aptamer-conjugated semiconducting nanoparticles

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dc.creator ODACI DEMIRKOL, Dilek
dc.creator GULEC, Kadri
dc.date 2018-10-05T00:00:00Z
dc.date.accessioned 2019-07-09T12:00:36Z
dc.date.available 2019-07-09T12:00:36Z
dc.identifier http://dergipark.org.tr/sdufenbed/issue/39695/470085
dc.identifier
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/46827
dc.description Aptamers are selective molecules against to various sizes of targets from small molecules to mammalian cells. Here, we reported QDs containing electrochemical aptasensor for the detection of E. coli O157:H7. The electrode surfaces were modified by cysteamine (CysN), which has amine and thiol groups, via self-assembled monolayer formation. The carboxyl-functionalized quantum dots (QD) and aptamers (Apt) were conjugated to cysteamine modified gold electrodes. Linear range for E. coli O157:H7 was from 1 to 102 CFU/mL after incubation on CysN/QD/Apt modified Au surfaces. QDs provide fluorescence surface, so that adhesion of cells was followed using fluorescence microscope. Adhered cells were also imaged by scanning electron microscopy. Finally, cell analysis was carried out in real samples.
dc.format application/pdf
dc.publisher Süleyman Demirel University
dc.publisher Süleyman Demirel Üniversitesi
dc.relation http://dergipark.org.tr/download/article-file/552990
dc.source Cilt: 22 Sayı: Özel 421-426 en-US
dc.source 1308-6529
dc.subject E. coli O157:H7 sensing,Electrochemical detection; Fluorescence imaging; Quantum dots
dc.title Electrochemical sensing and fluorescence imaging of E. coli O157:H7 based on aptamer-conjugated semiconducting nanoparticles en-US
dc.type info:eu-repo/semantics/article


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