| dc.creator |
ERCAN, Sevim |
|
| dc.date |
2013-04-19T11:49:14Z |
|
| dc.date.accessioned |
2019-07-09T12:08:19Z |
|
| dc.date.available |
2019-07-09T12:08:19Z |
|
| dc.identifier |
http://dergipark.org.tr/sdutfd/issue/21012/225950 |
|
| dc.identifier |
10.17343/sdutfd.01472 |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/47310 |
|
| dc.description |
Lipid peroxidation and apoptosis levels in gastric tissue of spontaneously hypertensive ratsAim: The spontaneously hypertensive rat is a widely used animal model for essential hypertension . Despitethe recognized gastric complications of hypertension, such as bleeding from gastritis, gastric mucosal bloodflow and motility and vascular ectasias until now no investigations have been conducted on gastric mucosalapoptosis in hypertensive animals. In this study, we investigated the lipid peroxidation and apoptoticchanges in the stomachs on spontaneously hypertensive rats. Methods: Spontaneously hypertensive (n: 10)and normotensive Wistar Kyoto rats (n: 10) were used. Thiobarbituric acid reactive substances weredetermined as an indicator of lipid peroxidation and terminal deoxynucleotdyl transferase-mediateddeoxyuridine triphosphate nick-end labelling technique was used to detect apoptosis in gastric tissue. Results:While the number of apoptotic cells were increased significantly in spontaneously hypertensive rats,thiobarbituric acid reactive substances were not changed when compared Wistar Kyoto rats. In conclusion,data presented in the current study demonstrate the significant increase in gastric mucosal apoptosis inspontaneously hypertensive rats for the first time but underlying mechanisms of apoptosis are not clarified |
|
| dc.description |
AbstractLipid peroxidation and apoptosis in gastric tissue of spontaneously hypertensive ratsAim: The spontaneously hypertensive rat is a widely used animal model for essential hypertension . Despite the recognized gastric complications of hypertension, such as bleeding from gastritis, gastric mucosal blood flow and motility and vascular ectasias until now no investigations have been conducted on gastric mucosal apoptosis in hypertensive animals. In this study, we investigated the lipid peroxidation and apoptotic changes in the stomachs on spontaneously hypertensive rats. Methods: Spontaneously hypertensive (n: 10) and normotensive Wistar Kyoto rats (n: 10) were used. Thiobarbituric acid reactive substances were determined as an indicator of lipid peroxidation and terminal deoxynucleotdyl transferase-mediated deoxyuridine triphosphate nick-end labelling technique was used to detect apoptosis in gastric tissue. Results: While the number of apoptotic cells were increased significantly in spontaneously hypertensive rats, thiobarbituric acid reactive substances were not changed when compared Wistar Kyoto rats. In conclusion, data presented in the current study demonstrate the significant increase in gastric mucosal apoptosis in spontaneously hypertensive rats for the first time but underlying mechanisms of apoptosis are not clarified.Key words: Spontaneously hypertansive rat; apoptosis; gastric tissue; lipid peroxidation, |
|
| dc.format |
application/pdf |
|
| dc.language |
en |
|
| dc.publisher |
Süleyman Demirel University |
|
| dc.publisher |
Süleyman Demirel Üniversitesi |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/196933 |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/250316 |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/250317 |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/250318 |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/250319 |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/250320 |
|
| dc.source |
Volume: 20, Issue: 1
18-22 |
en-US |
| dc.source |
1300-7416 |
|
| dc.source |
2602-2109 |
|
| dc.subject |
Spontaneously hypertansive rat; apoptosis; gastric tissue; lipid peroxidation |
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| dc.subject |
Spontan hipertansif sýçan, apopitozis, mide dokusu, lipid peroksidasyon |
|
| dc.title |
Lipid peroxidation and apoptosis in gastric tissue of spontaneously hypertensive rats |
en-US |
| dc.type |
info:eu-repo/semantics/article |
|