| dc.creator |
Yetkin Ay, Zuhal |
|
| dc.creator |
Çağlar Özşahin, Fethiye |
|
| dc.creator |
Kumbul Doğuç, Duygu |
|
| dc.creator |
Harun Dağdeviren, Birsen |
|
| dc.creator |
Uskun, Ersin |
|
| dc.creator |
Kırzıoğlu, Fatma Yeşim |
|
| dc.date |
2017-01-03T00:00:00Z |
|
| dc.date.accessioned |
2019-07-09T12:12:17Z |
|
| dc.date.available |
2019-07-09T12:12:17Z |
|
| dc.identifier |
http://dergipark.org.tr/sdusbed/issue/32112/356018 |
|
| dc.identifier |
|
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/48203 |
|
| dc.description |
Objective: Interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF-α) are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats. Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats (NH, n = 8), normal weight rats with periodontitis (NP, n = 8), overweight, periodontally healthy rats (OH, n = 8); and overweight rats with periodontitis (OP, n = 8). Periodontitis was induced by ligature for 14 days. The serum cytokine’ and adipokine’ levels were investigated using ELISA. Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats (P <0.01). The IL-6 level was significantly higher in the OP group than in the NP group (P < 0.01). The adiponectin level was significantly higher in the NH group than in the OH and OP groups (P < 0.01). Leptin and resistin levels didn’t differ significantly among the groups (P > 0.01). Conclusions: The overweight status affected the cytokine’ and adipokine’ level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines (IL-4 and adiponectin) and higher serum levels of pro-inflammatory cytokine (IL-6) than their counterparts in normal weight rat groups. |
|
| dc.format |
application/pdf |
|
| dc.publisher |
Süleyman Demirel University |
|
| dc.publisher |
Süleyman Demirel Üniversitesi |
|
| dc.relation |
http://dergipark.org.tr/download/article-file/367746 |
|
| dc.source |
Volume: 7, Issue: 3
24-30 |
en-US |
| dc.source |
2146-1937 |
|
| dc.source |
2146-247X |
|
| dc.title |
The effect of the overweight on the circulating cytokines and adipokines |
en-US |
| dc.type |
info:eu-repo/semantics/article |
|