| dc.creator |
Yildiz, Ufuk |
|
| dc.creator |
AKKOÇ, Senem |
|
| dc.creator |
Gercek, Zuhal |
|
| dc.creator |
Sengul, Abdurrahman |
|
| dc.creator |
Coban, Burak |
|
| dc.creator |
Caymaz, Bahar |
|
| dc.date |
2020-06-30T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:15:41Z |
|
| dc.date.available |
2020-10-06T09:15:41Z |
|
| dc.identifier |
0023a6b5-e3c7-4e77-b264-b0ae836eaefc |
|
| dc.identifier |
10.1002/slct.202001580 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/0023a6b5-e3c7-4e77-b264-b0ae836eaefc/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/51855 |
|
| dc.description |
A novel benzimidazole-imidazo[1,2-a]pyridine hybrid; 2-(imidazo[1,2-a]pyridine-8-yl)benzimidazole and its symmetrical bis- derivative 2,2 '-bis-(imidazo[1,2-a]pyridine-8-yl)-1H,1H '-[5,5 ']-bisbenzimidazole were synthesized and characterized. It was found that these two compounds have a strong DNA groove binding and peroxide mediated DNA-cleavage properties. Furthermore, these molecules were screened against three different human cell lines namely HepG2, DLD-1 and MDA-MB-231, and these compounds were found to have high cytotoxic activities. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis, Characterization, and Antiproliferative Activity Studies of Novel Benzimidazole-Imidazopyridine Hybrids as DNA Groove Binders |
|
| dc.type |
info:eu-repo/semantics/article |
|