| dc.creator |
KARATAŞ, MERT OLGUN |
|
| dc.creator |
ALICI, BÜLENT |
|
| dc.creator |
Cakir, Umit |
|
| dc.creator |
Cetinkaya, Engin |
|
| dc.creator |
Demir, Dudu |
|
| dc.creator |
Ergun, Adem |
|
| dc.creator |
Gencer, Nahit |
|
| dc.creator |
Arslan, Oktay |
|
| dc.date |
2014-05-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:18:04Z |
|
| dc.date.available |
2020-10-06T09:18:04Z |
|
| dc.identifier |
03d7c948-4a9c-4e13-8c43-0961f1166210 |
|
| dc.identifier |
10.3109/21691401.2013.794352 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/03d7c948-4a9c-4e13-8c43-0961f1166210/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/52221 |
|
| dc.description |
In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
New coumarin derivatives as carbonic anhydrase inhibitors |
|
| dc.type |
info:eu-repo/semantics/article |
|