| dc.creator |
Culha, Mustafa |
|
| dc.creator |
Demiralay, Ebru |
|
| dc.creator |
Yilmaz, Hulya |
|
| dc.creator |
Cobandede, Zehra |
|
| dc.creator |
Yilmaz, Deniz |
|
| dc.creator |
Cinkilic, Ayse |
|
| dc.date |
2020-06-30T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:18:13Z |
|
| dc.date.available |
2020-10-06T09:18:13Z |
|
| dc.identifier |
053dbb67-d2a9-4744-a732-768fcc3b1309 |
|
| dc.identifier |
10.1016/j.talanta.2020.120828 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/053dbb67-d2a9-4744-a732-768fcc3b1309/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/52337 |
|
| dc.description |
Potential degradation products (DPs), even in small concentrations, can cause changes in pharmacological and toxicological properties of a drug with a significant impact on product quality and safety. Thus, their stability and understanding of possible degradation mechanisms have a significant importance. Although liquid chromatography is the conventional technique used for forced degradation studies with excellent accuracy and reproducibility, the main disadvantages of the technique are being expensive and time-consuming. As a powerful technique, surface-enhanced Raman scattering (SERS) can be an alternative with its high sensitivity, easy sample preparation and low cost. In this study, the degradation of both tofacitinib (TOF), a Janus kinase inhibitor, and methotrexate (MTX), an inhibitor of tetrahydrofolate dehydrogenase, are studied using SERS under hydrolytic, oxidative and thermal conditions using mesoporous silica coated silver nanoparticles (Si@AgNPs) as SERS substrates. The study demonstrated that the degradation of the tested drugs using Si@AgNPs as SERS substrates could be monitored through the spectral changes on SERS spectra of drugs under several degradation conditions. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Monitoring forced degradation of drugs using silica coated AgNPs with surface-enhanced Raman scattering |
|
| dc.type |
info:eu-repo/semantics/article |
|