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Chiral 2-(2-hydroxyaryl)alcohols (HAROLs) with a 1,4-diol scaffold as a new family of ligands and organocatalysts

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dc.creator TEZEREN, Mustafa A.
dc.creator DILEK, Omer
dc.creator TİLKİ, Tahir
dc.creator ERTURK, Erkan
dc.date 2018-01-10T21:00:00Z
dc.date.accessioned 2020-10-06T09:24:50Z
dc.date.available 2020-10-06T09:24:50Z
dc.identifier 0e7d655a-8b25-4d20-b937-07bf4a94a08b
dc.identifier 10.1016/j.tet.2017.11.054
dc.identifier https://avesis.sdu.edu.tr/publication/details/0e7d655a-8b25-4d20-b937-07bf4a94a08b/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/53309
dc.description Efficient and modular syntheses of chiral 2-(2-hydroxyaryl)alcohols (HAROLs), novel 1,4-diols carrying one phenolic and one alcohol hydroxyl group, have been developed which led to generation of a small library of structurally diverse HAROL5 in enantiomerically pure form: Of the different HAROLs examined, a HAROL based on the indan backbone exhibited the highest activity and enantioselectivity in the 1,2-addition of certain organometallic compounds to aldehydes in the presence of Ti((OPr)-Pr-i)(4) (up to 97% y, 88% ee) and performed as a hydrogen-bond donor organocatalyst in the Morita-Baylis-Hillman reaction, promoted by trialkylphosphines. (C) 2017 Elsevier Ltd. All rights reserved.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Chiral 2-(2-hydroxyaryl)alcohols (HAROLs) with a 1,4-diol scaffold as a new family of ligands and organocatalysts
dc.type info:eu-repo/semantics/article


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