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Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment

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dc.creator Ozdem, M.
dc.creator KOÇAK, Hüsamettin
dc.creator Sert, T.
dc.creator FENTOĞLU, Özlem
dc.creator Sutcu, R.
dc.creator KIRZIOĞLU, Fatma Yeşim
dc.date 2012-03-31T21:00:00Z
dc.date.accessioned 2020-10-06T09:27:07Z
dc.date.available 2020-10-06T09:27:07Z
dc.identifier 1647fdae-1213-473b-9857-6a0c3110c01e
dc.identifier 10.1111/j.1601-0825.2011.01880.x
dc.identifier https://avesis.sdu.edu.tr/publication/details/1647fdae-1213-473b-9857-6a0c3110c01e/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/54101
dc.description OBJECTIVE: The aim of this study was to evaluate the effects of periodontal treatment on serum and gingival crevicular fluid (GCF) proinflammatory cytokine levels in hyperlipidemic patients with periodontitis. MATERIALS AND METHODS: Fifty-two patients with hyperlipidemia and periodontitis and 28 systemically healthy controls with periodontitis (C) were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). The clinical periodontal parameters, fasting venous blood, and GCF samples were obtained, and serum tumor necrosis factor-alpha (TNF-a), interleukin (IL) 1-beta, and IL-6 levels were evaluated at baseline and at 3 months follow-up (3MFU) after the completion of the non-surgical periodontal treatment that included scaling and root planning. RESULTS: Percentage of bleeding on probing was significantly higher in the HS group than both the HD and C groups. In the HD and HS groups, there were significant decreases in serum IL-6 andGCFTNF-a levels between the 3MFUand baseline. Asignificant decrease was also found in GCF IL-6 at the end of the study period in the HS group. CONCLUSION: The combination of the periodontal therapy and antilipemic treatment may provide beneficial effects on the metabolic and inflammatory control of hyperlipidemia. Oral Diseases (2012) 18, 299-306
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment
dc.type info:eu-repo/semantics/article


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