| dc.creator |
Sogut, S. |
|
| dc.creator |
Yonden, Z. |
|
| dc.creator |
Kaya, H. |
|
| dc.creator |
Oktar, S. |
|
| dc.creator |
Tutanc, M. |
|
| dc.creator |
Yilmaz, H. R. |
|
| dc.creator |
Yigit, A. |
|
| dc.creator |
Ozcelik, N. |
|
| dc.creator |
Gali, E. |
|
| dc.date |
2010-12-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:27:22Z |
|
| dc.date.available |
2020-10-06T09:27:22Z |
|
| dc.identifier |
186a6cdf-066b-429a-87ee-2407333df6cb |
|
| dc.identifier |
10.4238/vol10-2gmr1106 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/186a6cdf-066b-429a-87ee-2407333df6cb/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/54296 |
|
| dc.description |
Oxidative stress may be contributory to the pathophysiology of the abnormalities that underlie the clinical course of sickle cell anemia. We looked for a possible genetic association between the functional polymorphism Ala-9Val in the human Mn-SOD gene and sickle cell anemia. One hundred and twenty-seven patients with sickle cell anemia and 127 healthy controls were recruited into the study. Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV. In the sickle cell anemia patients, the frequency of Val/Val genotype was approximately 1.4-fold lower and that of Ala/Val was 1.3-fold higher compared to the controls. No significant difference in genotype frequencies was found between patients and controls (chi(2) = 4.561, d.f. = 2, P = 0.101). The Val-9 was the most common allele in patient and healthy subjects. No significant difference in allele frequencies was found between patients and controls (chi(2) = 1.496, d.f. = 1, P = 0.221). We conclude that the Mn-SOD gene polymorphism is not associated with sickle cell anemia. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Ala-9Val polymorphism of Mn-SOD gene in sickle cell anemia |
|
| dc.type |
info:eu-repo/semantics/article |
|