| dc.creator |
DEVECİ, HACİ AHMET |
|
| dc.creator |
NUR, GÖKHAN |
|
| dc.creator |
Akyuva, Yener |
|
| dc.creator |
NAZIROĞLU, Mustafa |
|
| dc.date |
2019-02-28T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:32:39Z |
|
| dc.date.available |
2020-10-06T09:32:39Z |
|
| dc.identifier |
2493064c-2d28-4182-a59e-836528eaa45a |
|
| dc.identifier |
10.1016/j.biopha.2018.12.077 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/2493064c-2d28-4182-a59e-836528eaa45a/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/55531 |
|
| dc.description |
Apoptosis, overload Ca2+ entry and oxidative stress are induced in neurons by hypoxia. Drug-resistant cancer cells are killed by hypoxic conditions. a-Lipoic acid (ALA) has antioxidant and pro-oxidant functions. The TRPA1 channel is activated by oxidative stress and pro-oxidant ALA may have a regulator role in the TRPA1 activity in the human glioblastoma (DBTRG) cells. The aim of this study was to evaluate if a combination therapy of ALA with a hypoxia can alter the effect of this hypoxia through TRPA1 activation in the DBTRG cells. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line |
|
| dc.type |
info:eu-repo/semantics/article |
|