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Determination of pK(a) values of nonsteroidal antiinflammatory drug-oxicams by RP-HPLC and their analysis in pharmaceutical dosage forms

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dc.creator ALSANCAK, Guleren
dc.creator Ozkan, Sibel A.
dc.creator Demiralay, Ebru
dc.date 2009-08-31T21:00:00Z
dc.date.accessioned 2020-10-06T09:35:39Z
dc.date.available 2020-10-06T09:35:39Z
dc.identifier 2720e5fc-339c-4943-bb00-557e89b0843e
dc.identifier 10.1002/jssc.200900234
dc.identifier https://avesis.sdu.edu.tr/publication/details/2720e5fc-339c-4943-bb00-557e89b0843e/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/55785
dc.description In this study, pK(a) values were determined by using the dependence of the capacity factor on the pH of the mobile phase for four ionizable substances, namely, tenoxicam, piroxicam, meloxicam, and naproxen (I.S.). The effect of the mobile phase composition on the ionization constant was studied by measuring the pK(a) at different ACN concentrations, ranging from 30 to 40%. The adequate condition for the chromatographic determination of these compounds in pharmaceutical dosage forms was established based on the different retention behaviors of the species. An octadecylsilica Nucleosil C18 column (150 x 4.6 mm, 5 mu m) was used for all the determinations. The chromatographic separation of oxicams was carried out using acetonitrile (ACN)/water at 35% v/v, containing 65 mM phosphoric acid and UV detection at a wavelength of 355 nm. The method developed was successfully applied to the simultaneous determination of these drug compounds in laboratory-prepared mixtures and their commercial pharmaceutical dosage forms. Each analysis requires no longer than 12 min.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Determination of pK(a) values of nonsteroidal antiinflammatory drug-oxicams by RP-HPLC and their analysis in pharmaceutical dosage forms
dc.type info:eu-repo/semantics/article


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