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Activated Protein C and Normal Saline Infusion Might Prevent Deleterious Effects of Remote Acute Lung Injury Caused by Intestinal Ischemia-Reperfusion: An Experimental Study in the Rat Model

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dc.creator TARHAN, Ömer Rıdvan
dc.creator Ceylan, Berit Gokce
dc.creator Kapucuoglu, Nilgun
dc.creator Sutcu, Recep
dc.creator Kumbul, Kadir
dc.date 2011-05-31T21:00:00Z
dc.date.accessioned 2020-10-06T09:35:49Z
dc.date.available 2020-10-06T09:35:49Z
dc.identifier 2843fe73-29ae-4343-89ba-7a22d40b884f
dc.identifier 10.1016/j.jss.2009.12.002
dc.identifier https://avesis.sdu.edu.tr/publication/details/2843fe73-29ae-4343-89ba-7a22d40b884f/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/55905
dc.description Background. Intestinal ischemia-reperfusion is a common medical event associated with both clinical and experimental distant organ injury. In particular, the lung tissue appears to be susceptible to injury resulting from systemic inflammatory mediator activation. Drotrecogin alpha (activated) or recombinant human activated protein C has antithrombotic, anti-inflammatory, and profibrinolytic properties. We hypothesized that APC infusion would decrease lung inflammation and ameliorate lung injury resulting from intestinal ischemia-reperfusion (IIR). A rat model of intestinal ischemia-reperfusion was used to test this hypothesis, and several parameters of lung injury were measured in lung samples.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Activated Protein C and Normal Saline Infusion Might Prevent Deleterious Effects of Remote Acute Lung Injury Caused by Intestinal Ischemia-Reperfusion: An Experimental Study in the Rat Model
dc.type info:eu-repo/semantics/article


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