| dc.creator |
POTURCU, Kader |
|
| dc.creator |
ÇUBUK DEMİRALAY, Ebru |
|
| dc.date |
2019-05-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:36:34Z |
|
| dc.date.available |
2020-10-06T09:36:34Z |
|
| dc.identifier |
2e6404ea-75a9-4b13-860a-68c30def04cc |
|
| dc.identifier |
10.1021/acs.jced.9b00131 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/2e6404ea-75a9-4b13-860a-68c30def04cc/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/56485 |
|
| dc.description |
In this study, the retention behavior of benzimidazole anthelmintic drug mebendazole (MBZ) was investigated with a liquid chromatographic method. Influence of acetonitrile (ACN) concentration present in the mobile phase on retention measurement was examined. Analyses were carried out with a Kinetex Core-Shell C8 (Phenomenex, 150 x 4.6 mm I.D., 2.6 mu;m) column at 25 degrees C. The mobile phase pH ((s)(s)pH) values were measured in ACN + water mixtures. By using the retention data obtained from this chromatographic analysis, thermodynamic dissociation constant (pK(a)) values of the mebendazole were investigated experimentally at a constant flow rate. Experimental data were analyzed by using a nonlinear regression program. This is the first time that the pH-retention time relationships of MBZ were evaluated by the experimental method. Moreover, the pK(a) values at 37 degrees C, solubility (log S-w), and lipophilicity (log P-o/w) were calculated by using Abrahams solute descriptors. The pK(a) values obtained from this study complied with the literature data acquired from other methods. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Determination of Some Physicochemical Properties of Mebendazole with RPLC Method |
|
| dc.type |
info:eu-repo/semantics/article |
|