| dc.creator |
ICLI, Atilla |
|
| dc.creator |
DOGAN, Abdullah |
|
| dc.creator |
ARSLAN, Akif |
|
| dc.creator |
AKSOY, Fatih |
|
| dc.creator |
VAROL, Ercan |
|
| dc.creator |
UYSAL, Bayram Ali |
|
| dc.creator |
Ozaydin, Mehmet |
|
| dc.creator |
ERDOGAN, Dogan |
|
| dc.date |
2012-05-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:39:52Z |
|
| dc.date.available |
2020-10-06T09:39:52Z |
|
| dc.identifier |
3426fba2-02d7-44e2-9a7c-462dd9f5fc11 |
|
| dc.identifier |
10.1097/mbc.0b013e328352cb21 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/3426fba2-02d7-44e2-9a7c-462dd9f5fc11/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/57066 |
|
| dc.description |
We investigated the association of mean platelet volume (MPV) with culprit lesion severity and major cardiac outcomes (MCOs) in patients with acute coronary syndrome (ACS) with non-ST elevation (NSTE). This study included 344 patients with NSTE-ACS who had significant coronary stenosis at least 50%. They were divided into high MPV group (n=109, upper tertile >9.9 fl) and low MPV group (n=235, lower and mid tertile <= 9.9 fl) according to MPV values on admission. They were followed up for MCOs during 12 months. MCO consisted of the composite end-point of cardiac death, myocardial infarction (MI), recurrent angina or hospitalization. High MPV was independently associated with NSTE-MI [odds ratio (OR) 4.24, 95% confidence interval (CI) 2.52-7.15, P=0.001] and severe culprit stenosis (>= 80%) (OR 4.05, 95% CI 2.39-6.83, P=0.001). MPV of 9.9 fl was predictive of severe culprit stenosis with a sensitivity of 73% and specificity of 77% (P<0.001). At 12 months, MCO rate was higher in high MPV group than low MPV group (39 vs. 26%; P=0.016). This difference resulted from death (6.4 vs. 2.1; P=0.06) and recurrent angina (16.5 vs. 8.9%; P=0.045). The MCO-free survival was worse in patients with high MPV than those with low MPV (61 vs. 74%; P=0.01). In Cox regression analysis, high MPV remained an independent predictor of MCO (hazard ratio 1.52, 95% CI 1.01-2.29, P=0.04) after adjusting for baseline characteristics. Elevated MPV was independently associated with NSTE-MI presentation and severity of culprit stenosis in NSTE-ACS patients. Moreover, MPV greater than 9.9 fl was predictive of a 12-month MCO. Blood Coagul Fibrinolysis 23: 324-330 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation |
|
| dc.type |
info:eu-repo/semantics/article |
|