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Chiral 1,4-aminoalkylphenols for enantioselective diethylzinc addition to aldehydes

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dc.creator Dilek, Omer
dc.creator Tezeren, Mustafa Ali
dc.creator Erturk, Erkan
dc.creator TİLKİ, Tahir
dc.date 2018-12-31T21:00:00Z
dc.date.accessioned 2020-10-06T09:47:34Z
dc.date.available 2020-10-06T09:47:34Z
dc.identifier 39b9a030-c9e9-498a-8c02-57537bb3b7a2
dc.identifier 10.3906/kim-1810-78
dc.identifier https://avesis.sdu.edu.tr/publication/details/39b9a030-c9e9-498a-8c02-57537bb3b7a2/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/57649
dc.description Starting from a chiral secondary alcohol, novel enantiopure 1,4-aminoalkylphenols (AAPs) were prepared by exploiting conventional organic transformations such as the Mitsunobu reaction, Eschweiler-Clarke N-methylation, and demethylation of anisoles. The catalytic activity of the 1,4-AAPs was investigated in enantioselective Et2Zn addition to benzaldehyde. They were found to accelerate the Et2Zn addition to benzaldehyde. High yields and enantioselectivities (e.g., 95% yield and 82% ee) were achieved.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Chiral 1,4-aminoalkylphenols for enantioselective diethylzinc addition to aldehydes
dc.type info:eu-repo/semantics/article


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