| dc.creator |
KUMBUL DOĞUÇ, Duygu |
|
| dc.creator |
YILDIZ, Mustafa |
|
| dc.creator |
CESUR, GÖKHAN |
|
| dc.creator |
Ongel, Kurtulus |
|
| dc.creator |
Ogut, Serdal |
|
| dc.creator |
Polat, Mumin |
|
| dc.date |
2014-02-28T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:48:04Z |
|
| dc.date.available |
2020-10-06T09:48:04Z |
|
| dc.identifier |
3daa4633-c9af-4c33-be2e-1a70dc59f6eb |
|
| dc.identifier |
10.1177/0748233712452599 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/3daa4633-c9af-4c33-be2e-1a70dc59f6eb/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/58033 |
|
| dc.description |
Nuclear medicine has been using radiopharmaceuticals for the diagnostic and therapeutic purposes of many diseases. Technetium-(99m) methoxyisobutylisonitrile (Tc-99m sestamibi) is a lypophilic complex that has a positive-loaded isonitril group. Aim of the study is to investigate whether Tc-99m sestamibi, which is one of the mostly used radiopharmaceuticals in nuclear medicine field, causes oxidative damage or not in rats' heart after an injection. A total of 16 male Sprague Dawley rats were randomly divided into two groups: group I: Tc-99m sestamibi group, Tc-99m sestamibi administered intravenously with the dose of 25MBq; group II: control group, one dose of isotonic sodium chloride was administered intravenous with the same volume as Tc-99m sestamibi group. Malondialdehyde (MDA) and total oxidant status (TOS) were used as markers of oxidative stress-induced heart impairment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant status (TAS) activities were studied to evaluate the changes in the antioxidant status. In the Tc-99m sestamibi group (group I), animals treated with Tc-99m sestamibi produced a significant decrease in the activities of antioxidant enzymes (SOD and CAT), while MDA level increased when compared with control group (group II) in myocardial tissue (p<0.05). On the other hand, the GSH-Px activities were significantly increased in the Tc-99m sestamibi-treated rats compared with the untreated rats (p<0.05). There was no significant difference in the TAS and TOS levels of plasma. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Effects of Tc-99m sestamibi on antioxidant defense system and lipid peroxidation in the heart of Sprague Dawley rats |
|
| dc.type |
info:eu-repo/semantics/article |
|