| dc.creator |
Savas, Serpil |
|
| dc.creator |
KAYA, Selçuk |
|
| dc.creator |
CETIN, Emel Sesli |
|
| dc.creator |
CEYHAN, Ali Murat |
|
| dc.creator |
DEMİRCİ, Mustafa |
|
| dc.creator |
Aridogan, Buket |
|
| dc.creator |
YILDIRIM, Mehmet |
|
| dc.creator |
URAL, Onur |
|
| dc.creator |
Akkus, Selami |
|
| dc.date |
2011-09-22T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:48:31Z |
|
| dc.date.available |
2020-10-06T09:48:31Z |
|
| dc.identifier |
40d51380-4179-4b66-8395-ac98c52a97d6 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/40d51380-4179-4b66-8395-ac98c52a97d6/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/58355 |
|
| dc.description |
In Behcet's disease (BD) and Brucellosis, joint involvement is very common and it may share similarities with rheumatoid arthritis (RA). Anti-cyclic citrullinated peptides (CCP) are evaluated as more specific autoantibodies than rheumatoid factor (RF) in RA. The aim of this study is to determine whether anti-CCP antibodies are useful in the differential diagnosis of RA from other arthritis or not. 153 serum samples were used in the study; 34 from RA patients, 26 from brucellar arthritis, 20 from BD with arthritis, 41 from BD without arthritis and 32 from healthy controls. In vitro quantitative, anti-CCP levels were measured by using fluoroenzyme-immunoassay (FEIA) method. Among RA patients, 73.5% were anti-CCP-positive and 70.5% were RF-positive. While there was a statistical difference in the anti-CCP and RF positivity rates between RA and brucellar arthritis patients, BD patients and healthy controls (p = 0.0001), there was no statistical difference between BD patients with arthritis and BD patients without arthritis. Also none of the Brucellar arthritis patients was positive for anti-CCP antibodies, one of them were positive for RF. Our results indicate that anti-CCP antibodies are not associated with brucellar arthritis or BD with joint involvement and since they show high specificity and good sensitivity for RA, they can be evaluated as a better marker than RF especially for the differentiation of RA from other types of arthritis such as BD and brucellar arthritis. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis, brucellar arthritis and Behcet's disease |
|
| dc.type |
info:eu-repo/semantics/article |
|