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Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

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dc.creator Kaya, Hakan
dc.creator Desdicioglu, Raziye
dc.creator Ozkaya, Okan
dc.creator Yimaztepe, Arzu
dc.creator Demirci, Meral
dc.creator SEZİK, Mekin
dc.creator ULUKAYA, Engin
dc.date 2008-02-29T22:00:00Z
dc.date.accessioned 2020-10-06T09:48:37Z
dc.date.available 2020-10-06T09:48:37Z
dc.identifier 41936c41-a069-44db-ae09-662e98882199
dc.identifier 10.1016/j.fertnstert.2007.03.065
dc.identifier https://avesis.sdu.edu.tr/publication/details/41936c41-a069-44db-ae09-662e98882199/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/58434
dc.description The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
dc.type info:eu-repo/semantics/article


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