| dc.creator |
Er, Mustafa |
|
| dc.creator |
Coskun, Necdet |
|
| dc.date |
2008-12-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:49:21Z |
|
| dc.date.available |
2020-10-06T09:49:21Z |
|
| dc.identifier |
470ced83-d0fc-403c-bf4c-737ab07a8838 |
|
| dc.identifier |
10.3998/ark.5550190.0010.c13 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/470ced83-d0fc-403c-bf4c-737ab07a8838/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/58983 |
|
| dc.description |
The one-pot azidation and benzoylation of a mixture of cis (-)-menthyl phenylglycidates provide quantitatively the corresponding (2R,3S)-, and (2S,3R)-3-azido-1-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-1-oxo-3-phenylpropan-2-yl benzoate. Enantiopure (2R,3S)-3-azido-1((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)-1-oxo-3-phenylpropan-2-yl benzoate crystallize from MeOH at room temperature in high yields. The reduction of the latter with Zn-TMSCl produces (-)-menthyl 3-benzamido-3-phenyl-2-(trimethylsilyloxy) propanoate which upon simultanious desilylation and hydrolysis provide the taxol side chain N-benzoyl-(2R, 3S)-3-phenylisoserine. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
cis-(-)-Menthyl phenylglycidates in the asymmetric synthesis of taxol side chain |
|
| dc.type |
info:eu-repo/semantics/article |
|