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Spectrophotometric Simultaneous Determination of Caffeine and Paracetamol in Commercial Pharmaceutical by Principal Component Regression, Partial Least Squares and Artificial Neural Networks Chemometric Methods

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dc.creator AKTAŞ, Ahmet Hakan
dc.creator KITIS, Filiz
dc.date 2014-03-31T21:00:00Z
dc.date.accessioned 2020-10-06T09:49:45Z
dc.date.available 2020-10-06T09:49:45Z
dc.identifier 4a27ba61-5797-4ad4-b473-ef8ceed2f5aa
dc.identifier 10.5562/cca2214
dc.identifier https://avesis.sdu.edu.tr/publication/details/4a27ba61-5797-4ad4-b473-ef8ceed2f5aa/oai
dc.identifier.uri http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/59298
dc.description Three multivariate calibration-prediction techniques, principal component regression (PCR), partial least squares (PLS) and artificial neural networks (ANN) were applied to the spectrometric multicomponent analysis of the drug containing paracetamol (PCT) and caffeine (CAF) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of PCT and CAF were used to check the prediction ability of the PCR, PLS and ANN. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the drug.
dc.language eng
dc.rights info:eu-repo/semantics/closedAccess
dc.title Spectrophotometric Simultaneous Determination of Caffeine and Paracetamol in Commercial Pharmaceutical by Principal Component Regression, Partial Least Squares and Artificial Neural Networks Chemometric Methods
dc.type info:eu-repo/semantics/article


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