| dc.creator |
BURHANOĞLU, ENDER |
|
| dc.creator |
Kosar, P. A. |
|
| dc.creator |
Aksoy, Müge |
|
| dc.date |
2018-07-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:49:56Z |
|
| dc.date.available |
2020-10-06T09:49:56Z |
|
| dc.identifier |
4b777dba-60f2-4dd0-ac80-5c336fd98db2 |
|
| dc.identifier |
10.4103/njcp.njcp_434_17 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/4b777dba-60f2-4dd0-ac80-5c336fd98db2/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/59428 |
|
| dc.description |
Background and Purpose: The investigators designed and implemented a prospective cohort study composed of smoking and nonsmoking patients with asymptomatic fully impacted mandibular third molars. The objective of the paper was to evaluate 21 single-nucleotide polymorphisms (SNP) on the TP53 gene in smokers' (S) and nonsmokers' (NS) pericoronal follicles of asymptomatic impacted third molars. Materials and Methods: Matrix-assisted desorption/ionization time of the flight mass spectrometry was used for SNP analysis of 21 regions in the TP53 gene. Descriptive statistics and Chi-square tests were computed with a P value of 0.05. Results: Ten of the 21 SNPs related to oral pathologies according to NCBI dbSNP, were detected; in these, the genotypic frequencies showed no differences between the S and NS groups (P > 0.05). The results showed a high ratio of SNPs without correlation between smoking and TP53 gene status. Conclusion: Further studies should examine the entire TP53 gene to elucidate how smoking affects it in larger study populations. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
TP53 Polymorphisms in Smokers' and Nonsmokers' Pericoronal Follicles of Asymptomatic Impacted Third Molars |
|
| dc.type |
info:eu-repo/semantics/article |
|