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<div class="h6 abstract-title" style="margin: 0px 0px 0.25rem; padding: 0px 0px 0.25rem; font-size: 2.125rem; font-family: franklin_gothic, "Helvetica Neue", Helvetica, Arial, sans-serif; line-height: 1.2; -webkit-font-smoothing: antialiased; color: rgb(28, 28, 28); letter-spacing: normal;">Abstract</div><p style="margin-bottom: 1.25rem; padding: 0px; font-family: "Open Sans", "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 16px; line-height: 1.8; text-rendering: optimizelegibility; -webkit-font-smoothing: antialiased; color: rgb(28, 28, 28);"><span style="font-weight: 600; line-height: inherit;">Purpose: </span>: To investigate functional outcomes and effectiveness of wet<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>field photo therapeutic keratectomy (PTK) for the treatment<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>of superficial central stromal corneal opacities.<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"></span></p><p style="margin-bottom: 1.25rem; padding: 0px; font-family: "Open Sans", "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 16px; line-height: 1.8; text-rendering: optimizelegibility; -webkit-font-smoothing: antialiased; color: rgb(28, 28, 28);"><span style="font-weight: 600; line-height: inherit;">Methods: </span>: 24 eyes of 12 patients with central superficial stromal opacities<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>treated with 193 nm excimer laser PTK between October 2004 and<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>June 2009 were included. Opacities were caused by macular corneal<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>dystrophy in 24 eyes. After epithelial debridement with 20%<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>isopropyl alcohol; PTK was performed under 0.5% topical proparacaine<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>HCL anesthesia. We applied balanced salt solution (BSS) irrigation<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>to the corneal surface to wet and fill the valleys of prominent<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>superficial corneal lesions, and Wet PTK was performed to the<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>protruded stromal opacities and irregularities. The procedure<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>repeated until the clearance of central lesions. Pre-set laser<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>ablation depth was 100 µm; ablation zone was 7 to 9 mm.<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>Actual ablated stromal depth was 65 µm±22 µm.<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>Main outcome measures included uncorrected visual acuity (UCVA)<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>and best corrected visual acuity (BCVA).<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"></span></p><p style="margin-bottom: 1.25rem; padding: 0px; font-family: "Open Sans", "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 16px; line-height: 1.8; text-rendering: optimizelegibility; -webkit-font-smoothing: antialiased; color: rgb(28, 28, 28);"><span style="font-weight: 600; line-height: inherit;">Results: </span>: Mean age of the patients was 29.14 (18-68 years). Mean follow<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>up was 4.2 ±2.3 years. UCVA increased from 0.75±0.5<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>(LogMAR) to 0.32±0.13 (LogMAR) after surgery. BCVA increased<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>from 0.34±0.13 (LogMAR) to 0.16±0.12 (LogMAR)<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>after surgery. There have been no clinically significiant recurrence<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>was confirmed in macular dystrophies during follow up period.<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"></span></p><p style="margin-bottom: 1.25rem; padding: 0px; font-family: "Open Sans", "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 16px; line-height: 1.8; text-rendering: optimizelegibility; -webkit-font-smoothing: antialiased; color: rgb(28, 28, 28);"><span style="font-weight: 600; line-height: inherit;">Conclusions: </span>: Wet field PTK is effective in removing central stromal opacities<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>and increasing visual acuity, especially for superficial and<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>centrally weighted macular dystrophy cases. More studies with<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>longer follow up times are needed for more definite results<span style="font-size: 12px; line-height: 0; position: relative; vertical-align: baseline; top: -0.5em;"> </span>to explain the low incidence of recurrences in our series.</p> |
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