| dc.creator |
Koroglu, Nadiye |
|
| dc.creator |
Yuksel, Ilkbal Temel |
|
| dc.creator |
Cetin, Berna Asian |
|
| dc.creator |
Turhan, Ugur |
|
| dc.creator |
Topcu, Goknur |
|
| dc.creator |
Dag, Ismail |
|
| dc.creator |
Tola, Esra |
|
| dc.date |
2019-08-17T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T09:50:30Z |
|
| dc.date.available |
2020-10-06T09:50:30Z |
|
| dc.identifier |
4f7a6f4e-339b-43b8-9353-7d58050f0cea |
|
| dc.identifier |
10.1080/14767058.2018.1448774 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/4f7a6f4e-339b-43b8-9353-7d58050f0cea/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/59862 |
|
| dc.description |
Objective: To investigate Phosphorylated adenosine monophosphate activated protein kinase (AMPK) levels in healthy pregnant women and pregnant women with preeclampsia (PE). Methods: Twenty-eight women with mild-PE, 22 with severe-PE, and 30 normotensive controls were included in this cross-sectional study. The serum AMPK levels of these patients were analyzed. The patients were followed up to delivery. Results: No statistically significant difference was found between the groups for age, gravida, parity, and gestational age at the time the blood samples were obtained (p > .05). No significant difference between the group with mild-PE and the control group was found, while in the severe-PE group, serum AMPK levels were significantly higher relative to both the mild-PE and control groups (p < .001 and p < .001, respectively). No correlation was detected between serum AMPK levels and age, body mass index (BMI), and gestational age at the time the blood samples were collected. A negative correlation was found between AMPK levels and gestational week and birthweight at delivery, while a positive correlation was detected between systolic and diastolic blood pressures and AMPK levels. Conclusions: Serum AMPK was higher in patients with severe-PE compared with healthy pregnant women and patients with PE without severe features so it might be a new biomarker for the prediction of disease and its severity. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Maternal serum AMP-activated protein kinase levels in mild and severe preeclampsia |
|
| dc.type |
info:eu-repo/semantics/article |
|