| dc.creator |
Ceyhan, Ali Murat |
|
| dc.creator |
Akkaya, Vahide Baysal |
|
| dc.creator |
Gulecol, Seyma Celik |
|
| dc.creator |
Ozguner, Fehmi |
|
| dc.creator |
Chen, WenChieh |
|
| dc.creator |
Ceyhan, Betul Mermi |
|
| dc.date |
2012-08-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:14:57Z |
|
| dc.date.available |
2020-10-06T10:14:57Z |
|
| dc.identifier |
5a434163-205c-4ade-91d0-5cf2c902da06 |
|
| dc.identifier |
10.1007/s00403-012-1205-9 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/5a434163-205c-4ade-91d0-5cf2c902da06/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/60929 |
|
| dc.description |
In recent times, there is widespread use of 2.45-GHz irradiation-emitting devices in industrial, medical, military and domestic application. The aim of the present study was to investigate the effect of 2.45-GHz electromagnetic radiation (EMR) on the oxidant and antioxidant status of skin and to examine the possible protective effects of beta-glucans against the oxidative injury. Thirty-two male Wistar albino rats were randomly divided into four equal groups: control; sham exposed; EMR; and EMR + beta-glucan. A 2.45-GHz EMR emitted device from the experimental exposure was applied to the EMR group and EMR + beta-glucan group for 60 min daily, respectively, for 4 weeks. beta-glucan was administered via gavage at a dose of 50 mg/kg/day before each exposure to radiation in the treatment group. The activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), as well as the concentration of malondialdehyde (MDA) were measured in tissue homogenates of the skin. Exposure to 2.45-GHz EMR caused a significant increase in MDA levels and CAT activity, while the activities of SOD and GSH-Px decreased in skin tissues. Systemic beta-glucan significantly reversed the elevation of MDA levels and the reduction of SOD activities. beta-glucan treatment also slightly enhanced the activity of CAT and prevented the depletion of GSH-Px activity caused by EMR, but not statistically significantly. The present study demonstrated the role of oxidative mechanisms in EMR-induced skin tissue damages and that beta-glucan could ameliorate oxidative skin injury via its antioxidant properties. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Protective effects of beta-glucan against oxidative injury induced by 2.45-GHz electromagnetic radiation in the skin tissue of rats |
|
| dc.type |
info:eu-repo/semantics/article |
|