| dc.creator |
Oral, Baha |
|
| dc.creator |
Guney, Mehmet |
|
| dc.creator |
Demirin, Hilmi |
|
| dc.creator |
Ozguner, Meltem |
|
| dc.creator |
Giray, Seren Gulsen |
|
| dc.creator |
Mungan, Tamer |
|
| dc.creator |
Altuntas, Irfan |
|
| dc.creator |
Take, Gulnur |
|
| dc.date |
2006-10-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:25:20Z |
|
| dc.date.available |
2020-10-06T10:25:20Z |
|
| dc.identifier |
6484e973-4ef8-48eb-9769-7de5f4105757 |
|
| dc.identifier |
10.1016/j.reprotox.2006.08.003 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/6484e973-4ef8-48eb-9769-7de5f4105757/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/61952 |
|
| dc.description |
We aimed to investigate the effect of subchronic administration of dichlorvos (DDVP) on endometrium and to evaluate ameliorating effects of a combination of Vitamins E and C against DDVP toxicity in the rat. Three groups of rats were used in the experiment. The first group was treated with 4 mg/kg DDVP; the second group was treated with 4 mg/kg body weight DDVP plus Vitamins E and C (DDVP + Vit); the third group was given only corn oil (control). DDVP and DDVP + Vit groups were given DDVP by gavage 5 days a week for 4 weeks at a dose level of 4 mg/kg day by using corn oil as the vechicle. Vitamins E and C were injected at doses of 50 mg/kg i.m. and 20 mg/kg body weight i.p. Histopathological and immunohistochemical examinations for caspase-3 and caspase-9 were accomplished in the endometrium. The level of malondialdehyde (MDA) increased significantly in the DDVP group compared with the control group (p < 0.05). MDA significantly decreased in the DDVP + Vit group compared with the DDVP group (p < 0.05). Administration of Vitamins E and C along with DDVP significantly reduced the histopathological changes and the extent of apoptosis. In conclusion, subchronic DDVP administration caused endometrial damage and that treatment with a combination of Vitamins E and C reduced endometrial damage caused by DDVP. (c) 2006 Elsevier Inc. All rights reserved. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Endometrial damage and apoptosis in rats induced by dichlorvos and ameliorating effect of antioxidant Vitamins E and C |
|
| dc.type |
info:eu-repo/semantics/article |
|