| dc.creator |
Demirci, Tuna |
|
| dc.creator |
Arslan, Mustafa |
|
| dc.creator |
Bilen, Cigdem |
|
| dc.creator |
Demir, Dudu |
|
| dc.creator |
Gencer, Nahit |
|
| dc.creator |
Arslan, Oktay |
|
| dc.date |
2014-01-31T22:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:25:30Z |
|
| dc.date.available |
2020-10-06T10:25:30Z |
|
| dc.identifier |
65af9dcf-e62b-4758-8a8a-1eb9619e2fa0 |
|
| dc.identifier |
10.3109/14756366.2012.757603 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/65af9dcf-e62b-4758-8a8a-1eb9619e2fa0/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/62077 |
|
| dc.description |
1,3-Dicarbonyl derivatives of methylaminobenzene-sulfonamide were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and hCA II were evaluated. hCA I and hCA II from human erythrocytes were purified by a simple one-step procedure by using Sepharose 4B-L-tyrosine-sulfanilamide affinity column. Our results show that the synthesized compounds inhibited the activity of carbonic anhydrase (CA) I and CA II. Among them, 2b and 2e were found to be the most active (IC50 = 2.12 and 2.52 mu M) for hCA I and hCA II, respectively. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide |
|
| dc.type |
info:eu-repo/semantics/article |
|