| dc.creator |
Koroglu, Nadiye |
|
| dc.creator |
Tayyar, Ahmet |
|
| dc.creator |
Tola, Esra Nur |
|
| dc.creator |
Yildirim, Gonca Yetkin |
|
| dc.creator |
Yuksel, Ilkbal Temel |
|
| dc.creator |
Cetin, Berna Aslan |
|
| dc.creator |
Acar, Deniz Kanber |
|
| dc.creator |
Dag, Ismail |
|
| dc.date |
2019-05-18T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:31:10Z |
|
| dc.date.available |
2020-10-06T10:31:10Z |
|
| dc.identifier |
6a944cfd-6209-456c-9186-2acc5d8d21f1 |
|
| dc.identifier |
10.1080/14767058.2017.1413546 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/6a944cfd-6209-456c-9186-2acc5d8d21f1/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/62567 |
|
| dc.description |
Objectives: To investigate liver-derived plasma protein fetuin B levels in healthy pregnant women and pregnant women with intrahepatic cholestasis of pregnancy (ICP). Materials and methods: Forty women with ICP and 40 healthy pregnant women were included in this cross-sectional study. The serum fetuin B levels of these patients were analyzed. The patients were followed up to delivery. Results: Maternal age, gravida, parity, BMI at assessment, and gestational age at blood sampling were similar between the ICP and control groups (p > .05). However, the gestational age at delivery and the birth weight were significantly lower in the ICP group (p < .05). Total bile acid (TBA) levels and liver function tests were significantly higher in the ICP group than in the control group (p < .0001 and < .0001, respectively). In addition, serum fetuin B concentrations were significantly higher in the ICP group than in the control group (p < .0001). The best cutoff for fetuin B serum concentration was 5540.2 pg/mL. Serum values greater than this threshold had 80% sensitivity and 65% specificity for the diagnosis of ICP. Conclusions: Serum fetuin B was higher in patients with ICP compared to healthy pregnant women and might be a new biomarker. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Increased levels of the novel hepatokine fetuin B in patients with intrahepatic cholestasis of pregnancy |
|
| dc.type |
info:eu-repo/semantics/article |
|