| dc.creator |
TEPEBASI, Muhammet Yusuf |
|
| dc.creator |
CALAPOGLU, Nilufer Sahin |
|
| dc.creator |
CALAPOĞLU, Mustafa |
|
| dc.date |
2016-09-30T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:31:15Z |
|
| dc.date.available |
2020-10-06T10:31:15Z |
|
| dc.identifier |
6b54d0d9-3f2e-437e-8453-4b29973b418d |
|
| dc.identifier |
10.1515/tjb-2016-0051 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/6b54d0d9-3f2e-437e-8453-4b29973b418d/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/62650 |
|
| dc.description |
Objective: A classic physiologic response to systemic hypoxia is the increase in red blood cell production. Hypoxia-inducible factors (HIFs) orchestrate oxygen-sensing machinery and hypoxic cell metabolism. Recent works suggest that mutation of the HIF oxygen-sensing pathway plays a key role in the pathogenesis of the erythrocytosis. In the present study, the probable role of the polymorphic HIF-1 alpha variants, C1772T (P582S) (rs11549465) and G1790A (A588T) (rs115494657), which are known to enhance transcriptional activity, were evaluated in the etiology of the polycythemia. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Investigation of hypoxia-inducible factor-1alpha (HIF-1 alpha) gene polymorphisms in individuals with high levels of hemoglobin |
|
| dc.type |
info:eu-repo/semantics/article |
|