| dc.creator |
Tabur, Suzan |
|
| dc.creator |
Aksoy, Sefika Nur |
|
| dc.creator |
Korkmaz, Hakan |
|
| dc.creator |
Ozkaya, Mesut |
|
| dc.creator |
Aksoy, Nurten |
|
| dc.creator |
Akarsu, Ersin |
|
| dc.date |
2015-03-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:32:14Z |
|
| dc.date.available |
2020-10-06T10:32:14Z |
|
| dc.identifier |
731324dd-b2ea-427d-8607-68619f475b88 |
|
| dc.identifier |
10.1007/s13277-014-2889-6 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/731324dd-b2ea-427d-8607-68619f475b88/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/63397 |
|
| dc.description |
The aim of this study was to determine levels of serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an indicator of oxidant-induced DNA damage and oxidant status in patients with papillary thyroid carcinoma before and after surgery. This study included 25 patients with papillary thyroid carcinoma and age-matched 27 healthy controls. Total antioxidant status (TAS), total oxidant status (TOS), lipid hydroperoxide (LOOH), and 8-OHdG levels were measured. 8-OHdG levels were significantly higher in the preoperative papillary thyroid carcinoma (PTC) group compared with the healthy control group (p<0.001) and were significantly lower after operation in patients with papillary thyroid carcinoma (p=0.004). Oxidative stress index (OSI) levels were significantly higher in both preoperative and postoperative PTC patients compared with the healthy control group (p<0.001 and p<0.001, respectively). TOS levels were higher in the preoperative and postoperative PTC groups compared to the healthy control group (p<0.001 and p<0.001, respectively). TAS levels was lower in the preoperative PTC groups compared to the healthy control group (p=0.011). Serum LOOH levels were higher in both preoperative and postoperative PTC groups compared to the healthy control group (p<0.001 and p<0.001, respectively). Correlation analysis yielded that serum 8-OHdG levels were positively correlated with OSI and LOOH levels in patients with PTC before surgery (r=0.668, p<0.001; r=0.446, p=0.025, respectively) and had a negative correlation with TAS levels (r=-0.616, p=0.001). We have shown severe oxidative DNA damage and impaired antioxidant status in papillary thyroid carcinoma. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma |
|
| dc.type |
info:eu-repo/semantics/article |
|