| dc.creator |
Büyükbayram, Hi |
|
| dc.creator |
Doğuç, Duygu |
|
| dc.creator |
Aydoğan Avşar, Pınar |
|
| dc.creator |
Işık, Ümit |
|
| dc.creator |
Aktepe, Evrim |
|
| dc.creator |
Kılıç, Faruk |
|
| dc.date |
2021-01-01T00:00:00Z |
|
| dc.identifier |
7b85e395-200f-4c93-9762-9725c21dee97 |
|
| dc.identifier |
10.1080/13651501.2020.1801754 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/7b85e395-200f-4c93-9762-9725c21dee97/oai |
|
| dc.description |
Objective This study aimed to investigate serum zonulin and claudin-5 levels of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls by controlling the parameters such as age, sex and body mass index (BMI) percentile which are known to affect these parameters. Method A total of 80 treatment-naive children and adolescents with ADHD and 40 healthy volunteer controls aged 8-12 years were enrolled in this study. The severities of ADHD symptoms were assessed via parent- and teacher-rated questionnaires. The severity of anxiety and depression symptoms of the children were assessed by the self-report inventories. Serum levels of zonulin and claudin-5 were measured using commercial enzyme-linked immunosorbent assay kits. Results The multivariate analysis of covariance (MANCOVA) revealed a significant main effect of groups in the serum zonulin and claudin-5 levels, an effect that was independent of age, sex and BMI percentile. Significant differences were found between the study groups in terms of serum log-claudin-5 levels. However, there was no significant difference between the study groups in terms of serum zonulin levels Conclusion These findings provide additional evidence for dysregulation of the blood-brain barrier, especially abnormalities in claudin-5 function, which may be involved in the aetiology of ADHD. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder |
|
| dc.type |
info:eu-repo/semantics/article |
|