| dc.creator |
DIRICAN, Nigar |
|
| dc.creator |
BAGCI, Ozkan |
|
| dc.creator |
UZ, Efkan |
|
| dc.creator |
ÖZTÜRK, Önder |
|
| dc.creator |
BİRCAN, Hacı Ahmet |
|
| dc.creator |
Dirican, Ahmet |
|
| dc.date |
2016-03-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:33:29Z |
|
| dc.date.available |
2020-10-06T10:33:29Z |
|
| dc.identifier |
7c7cf4ae-05bc-4973-8d87-ed9b4f03a1a3 |
|
| dc.identifier |
10.4328/jcam.4551 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/7c7cf4ae-05bc-4973-8d87-ed9b4f03a1a3/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/64329 |
|
| dc.description |
We described heterozygous deletion of tumor protein 53 (TP53) gene in 11 patients including 2 patients with non- malignant diseases (pneumonia) and 9 patients with malignant diseases [including small cell lung cancer (n = 3), non-small cell lung carcinoma (n = 4), non-Hodgkin's lymphoma (n= 1), and gastric carcinoma (n= 1)]. Chromosomal aberrant status was analyzed by fluorescence in situ hybridization with centromere specific and 17p13.1 locus specific probes. In 3 of 9 cancer patients we did not find malignant pleural effusion with histological examination and/or closed pleural biopsy. Heterozygous deletion of TP53 gene was found to be significantly higher in patients with malignant disease when compared to the patients with benign pleural fluid. As a result, we suggest that heterozygous deletion of TP53 may have indicator value for malignancy; however further studies are warranted to confirm this suggestion in large patient cohorts. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Evaluation of Heterozygous Deletion of TP53 Gene in Pleural Fluid Samples: A Case Series of 11 Patients |
|
| dc.type |
info:eu-repo/semantics/article |
|