| dc.creator |
Ejaz, Ahsan A. |
|
| dc.creator |
Nistor, Ionut |
|
| dc.creator |
Aslan, Gamze |
|
| dc.creator |
Aykanat, Asli |
|
| dc.creator |
Donciu, Mihaela-Dora |
|
| dc.creator |
Lanaspa, Miguel A. |
|
| dc.creator |
COVİC, Adrian |
|
| dc.creator |
SOLAK, Yalcin |
|
| dc.creator |
Johnson, Richard J. |
|
| dc.creator |
Afsar, Barış |
|
| dc.creator |
Kanbay, Mehmet |
|
| dc.creator |
Caglayan, Ozlem Hilal |
|
| dc.date |
2017-01-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:39:54Z |
|
| dc.date.available |
2020-10-06T10:39:54Z |
|
| dc.identifier |
7d632e67-5844-458a-bfb6-42e393b3de9f |
|
| dc.identifier |
10.1177/0003319716644395 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/7d632e67-5844-458a-bfb6-42e393b3de9f/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/64414 |
|
| dc.description |
Contrast-induced acute kidney injury (CI-AKI) is a common cause of hospital-acquired acute kidney injury (AKI). We evaluated the evidence that uric acid (UA) plays a pathogenic role in CI-AKI. Ten studies were eligible for inclusion for meta-analysis. Hyperuricemia predicted risk for cases with AKI in prospective cohort studies. Higher levels of serum UA (SUA), as defined by the authors, were associated with a 2-fold increased risk to develop AKI (pooled odds ratio 2.03; 95% confidence interval [CI] 1.48-2.78). Significant heterogeneity was found in cohort studies (P = .001, I-2 = 85.7%). In 2 clinical trials, lowering of SUA with saline hydration was significantly associated with reduced risk for AKI compared with saline hydration alone or saline hydration with N-acetyl cysteine. An analysis of 2 randomized controlled trials found that allopurinol with saline hydration had a significant protective effect on renal function (assessed by serum creatinine values) compared with hydration alone (mean difference: -0.52 mg/dL; 95% CI: -0.81 to -0.22). Hyperuricemia independently predicts CI-AKI. Two clinical trials suggest lowering SUA may prevent CI-AKI. The mechanism by which UA induces CI-AKI is likely related to acute uricosuria. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Serum Uric Acid and Risk for Acute Kidney Injury Following Contrast: An Evaluation of Epidemiology, Clinical Trials, and Potential Mechanisms |
|
| dc.type |
info:eu-repo/semantics/article |
|