| dc.creator |
AKTAŞ, Ahmet Hakan |
|
| dc.creator |
ERTOKUS, Guezide Pekcan |
|
| dc.date |
2008-03-31T21:00:00Z |
|
| dc.date.accessioned |
2020-10-06T10:40:04Z |
|
| dc.date.available |
2020-10-06T10:40:04Z |
|
| dc.identifier |
7ec1160f-2cd0-40e6-b26a-4028a197b692 |
|
| dc.identifier |
https://avesis.sdu.edu.tr/publication/details/7ec1160f-2cd0-40e6-b26a-4028a197b692/oai |
|
| dc.identifier.uri |
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/64552 |
|
| dc.description |
In present study, four antiinflammatory agents, namely naproxen, indomethacin, ibuprofen and etodolac were titrated potentiometrically using tetrabuthylammonium hydroxide in acetonitrile and 2-propanol solvents under nitrogen atmosphere at 25 degrees C. The ionization contants of several non-steroidal antiinflammatories have been determined potentiometrically in a series of acetonitrile. Four antiinflammatory agents are non-steroidal antiinflammatory drugs of the family of carboxylic weak acids. The results are compared with octanol-water media. Acetonitrile has a relatively high dielectric constant (epsilon = 36) and a small autoprotolysis constant (pK(s) = 33.6). Acetonitrile is higher dielectric constant than octanol. Because of this reason, ionization constant in acetonitrile is lower than in octanol-water mixtures. |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/closedAccess |
|
| dc.title |
Ionization constants and partition coefficient of some antiinflammatory agents in non-aqueous nedia |
|
| dc.type |
info:eu-repo/semantics/article |
|